How is hATTR amyloidosis passed down?

Hereditary ATTR (hATTR) amyloidosis is an autosomal dominant condition—meaning each child of one parent with hATTR amyloidosis has a 50% chance of inheriting a genetic variant, or change, that causes the condition. This change in the transthyretin (TTR) gene may also be referred to as a mutation.

How hATTR amyloidosis is inherited

When one parent carries an autosomal dominant variant, each child has a 50% chance of inheriting a genetic variant, or change, that causes this condition
Affected and Unaffected Icons
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A family member may inherit the TTR gene variant, but having the variant does not necessarily mean that they will develop hATTR amyloidosis.


“We’re a very close family, we share everything…if there’s a new symptom, we all want to know about it.”

SANDIE, living with hATTR amyloidosis